POWER LAB

GoodMomS 2 Study

Overview

GooDMomS2- A Bio-Behavioral Study

Of the 4 million women who give birth each year in the U.S., 7-14% (~240,000) will have been diagnosed with gestational diabetes mellitus(also known as GDM), depending on race/ethnicity, geography, and diagnostic thresholds. About 30% of those diagnosed will have GDM in the next pregnancy, and over time, mothers with GDM are at high risk for type 2 diabetes and cardiovascular disease (CVD) with hazard ratios of 5-10 for diabetes and 3-4 for CVD. Sustainable weight loss after delivery is a key factor for preventing diabetes and CVD. For every 1 kg of weight loss, there is a 16% reduction in diabetes riskand a 2 mmHg decrease in blood pressure.

In GooDMomS2, we expanded the scope of interventions. We propose an adaptive trial design among 60 participants to assess the effects of a DPP-based lifestyle intervention (LI) compared to an Enhanced Lifestyle intervention (ELI) that includes meal planning, compared to Metformin 750 mg twice daily.

Visit the GooDMomS website for more details.

Visit the GooDMomS website for more details.

Outcomes

  • Mean weight change at 6 months (primary)
  • Improvement in physical activity score
  • Physiological outcomes (change in blood pressure, A1c, lipids)
  • Wellness (quality of life, depression score) and lifestyle behaviors (diet quality, breastfeeding)
  • Adherence to Metformin treatment
  • Adverse events in either study arm.

Our Partners

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Other Studies

ALOFT Study

ALOFT-Assessing the Durability of Uterine Sparing Procedures and Quality of Life

A strength of ALOFT is that we utilized the infrastructure of COMPARE UF to extend long-term follow-up of women following uterine sparing procedures for symptomatic uterine fibroids.  In ALOFT, we are following ~1300 women up to 7-10 years following their index procedure to assess the impact on symptoms.

COMPARE-UF

By age 50, 50% of white women and 70% of black women will have symptomatic uterine fibroids. COMPARE UF is a prospective longitudinal study measuring quality of life outcomes following surgical intervention for uterine fibroids.

Our overall goals were to establish a national registry of women undergoing surgical interventions for uterine fibroids, to conduct a longitudinal follow-up of women following surgical interventions, assess women’s perception of their quality of life (QoL) following hysterectomy (removal of uterus) versus uterine sparing procedures (myomectomy, UAE, endometrial ablation). We found that women undergoing either hysterectomy or myomectomy had improved QoL scores, although those undergoing hysterectomy had slightly higher scores. Additionally, those with hysterectomy had better symptom severity scores and more improved depression scores.

DiabetesSisters Voices

This study aimed to develop and rigorously evaluate an online platform—the DiabetesSisters Network—to engage women with current or gestational diabetes. The goal was to create a virtual patient community that empowers participants to identify and prioritize topics for patient-centered and comparative effectiveness research.