POWER LAB

GoodMomS 2 Study

Overview

GooDMomS2- A Bio-Behavioral Study

Of the 4 million women who give birth each year in the U.S., 7-14% (~240,000) will have been diagnosed with gestational diabetes mellitus (also known as GDM), depending on race/ethnicity, geography, and diagnostic thresholds. About 30% of those diagnosed will have GDM in the next pregnancy, and over time, mothers with GDM are at high risk for type 2 diabetes and cardiovascular disease (CVD) with hazard ratios of 5-10 for diabetes and 3-4 for CVD. Sustainable weight loss after delivery is a key factor for preventing diabetes and CVD. For every 1 kg of weight loss, there is a 16% reduction in diabetes risk and a 2 mmHg decrease in blood pressure.

In GooDMomS2, we expanded the scope of interventions. We propose an adaptive trial design among 60 participants to assess the effects of a DPP-based lifestyle intervention (LI) compared to an Enhanced Lifestyle intervention (ELI) that includes meal planning, compared to Metformin 750 mg twice daily.

Visit the GooDMomS website for more details.

Outcomes

  • Mean weight change at 6 months (primary)
  • Improvement in physical activity score
  • Physiological outcomes (change in blood pressure, A1c, lipids)
  • Wellness (quality of life, depression score) and lifestyle behaviors (diet quality, breastfeeding)
  • Adherence to Metformin treatment
  • Adverse events in either study arm.

Our Partners

GW Med logo

Other Studies

ALOFT Study

Long Term Follow-up of Women who undergo Uterine-Sparing Fibroid Treatments 

This study will followup participants in the Comparing Options for Management: PAtient-centered REsults for Uterine Fibroids (COMPARE-UF) observational study to evaluate long-term quality of life measures 6-7 years following treatment for uterine fibroids.

COMPARE-UF

Sponsor: PCORI/AHRQ 

The objective of this project was to enable women with uterine fibroids, particularly minority and low-income women and childbearing age women, to make informed decisions about management options based on the highest possible quality evidence.

To help achieve this objective, we assembled 8 US centers to form a registry of a geographically, racially, ethnically, and clinically diverse group of women with uterine fibroids.

DiabetesSisters Voices

This study aimed to develop and rigorously evaluate an online platform—the DiabetesSisters Network—to engage women with current or gestational diabetes. The goal was to create a virtual patient community that empowers participants to identify and prioritize topics for patient-centered and comparative effectiveness research.